APOPTOSIS, OXIDATIVE STRESS AND NEUROLOGICAL DISEASE
نویسندگان
چکیده
منابع مشابه
Oxidative Stress and Human Disease: a Review
Background: The human body needs both types of oxidants (free radicals) and antioxidants for normal metabolism, signal transduction mechanism, and the order of cellular activity. Free radicals can be either harmful or helpful to the body, in fact, they play a dual role as both toxic and beneficial compounds. The human body has the natural antioxidant defense mechanism to counteract the free rad...
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Recently, clinical trials of several neurodegenerative diseases have increasingly targeted the evaluation of the effectiveness of various antioxidants. The results so far are encouraging but variable and thus confusing. Rationale for the possible clinical effectiveness of antioxidants in several degenerative conditions has arisen out of the many years of basic science generally showing that rea...
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متن کاملOxidative Stress, α-Synuclein, and Apoptosis in Parkinson’s Disease
Parkinson’s Disease is a neurodegenerative disease that is pathologically characterized by abnormal α-synuclein protein aggregation, dopamine depletion in nigrostriatal neurons, and the subsequent death of these neurons. Oxidative stress has been widely implicated as a cause for neurodegenerative diseases, especially Parkinson’s Disease (PD). The mechanisms by which oxidative stress occurs in P...
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Cerulein pancreatitis is similar to human edematous pancreatitis, manifesting with dysregulation of digestive enzyme production and cytoplasmic vacuolization, the death of acinar cells, edema formation, and infiltration of inflammatory cells into the pancreas. Reactive oxygen species are involved in nuclear factor-kappaB activation, cytokine expression, apoptosis and pathogenesis of pancreatiti...
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ژورنال
عنوان ژورنال: Journal of the Siena Academy of Sciences
سال: 2009
ISSN: 2279-8811,2279-882X
DOI: 10.4081/334